On Sunday, Valencia will welcome Real Madrid to Estadio Mestalla on matchday nine of LaLiga Santander in their first game after Geoffrey Kondogbia left the club for Atletico Madrid and with important absences for Zinedine Zidane's team.
The Frenchman will be without Dani Carvajal, Nacho Fernandez and Alvaro Odriozola due to injury, meaning that Lucas Vazquez will step in as fourth choice right-back again, while Mariano Diaz has also been ruled out with a strain which he is yet to recover from.
Beyond that, Eder Militao, Casemiro and Eden Hazard will all be watching from home having tested positive for COVID-19 this week, with the latter two having their cases confirmed late on this week.
The good news for Los Blancos will be the return of Martin Odegaard, who rejoined training this week and will be available for Zidane.
In midfield, Luka Modric replaces Toni Kroos while Vinicius and Marco Asensio line up either side of Karim Benzema in attack, and Marcelo and Isco have been given another chance in the XI.
For Valencia, Javi Gracia is forced to make changes for various reasons following the dramatic ending in the draw with Getafe last time out.
Valencia's confirmed line-up: Jaume Domenech; Daniel Wass, Gabriel Paulista, Hugo Guillamon, Jose Luis Gaya; Yunus Musah, Carlos Soler, Uros Racic, Denis Cheryshev; Kang-in Lee and Maxi Gomez.
Real Madrid's confirmed line-up: Thibaut Courtois; Lucas Vazquez, Raphael Varane, Sergio Ramos, Marcelo; Fede Valverde, Luka Modric, Isco; Marco Asensio, Karim Benzema and Vinicius Junior.